If I could change the science system, my prescription for changing the whole thing would be organising it around big goals and building teams to do it.
Every single cancer is a genetic disease. Not necessarily inherited from your parents, but it's genetic changes which cause cancer. So as we sequence the genomes of tumours and compare those to the sequence of patients, we're getting down to the fundamental basis of each individual person's cancer.
Early on, when you're working in a new area of science, you have to think about all the pitfalls and things that could lead you to believe that you had done something when you hadn't, and, even worse, leading others to believe it.
One of the things about genetics that has become clearer as we've done genomes - as we've worked our way through the evolutionary tree, including humans - is that we're probably much more genetic animals than we want to confess we are.
The trouble is the field of science, medicine, universities, biotech companies - you name it - have been so splintered, layers, sub-divided, hacked that people can spend their entire career studying one tiny little cog of life.